申请国外大学的推荐信

第一篇：申请国外大学的推荐信

申请报考浙江大学自主招生的自荐信

尊敬的浙江大学领导、老师：

您们好！

我叫，女，今年18岁，是省 县第一中学高

班学生。历经多年的学习和生活，经过不断的成长与进步，今天，我终于也像那些已进入理想大学的大哥哥、大姐姐们曾经的一样，面临着一次人生的重要选择。在此，首先感谢浙江大学的领导与老师给包括我在内的莘莘学子提供了这次自我推介、自我选择的宝贵机会！

对此，我的心情既兴奋又有点忐忑。兴奋的是经过反复思考，我终于下定了报考我心中的理想大学——浙江大学的决心；忐忑的是我这样的“丑小鸭”能否得到浙江大学这样全国一流大学的认可？

我生长在一个幸福的家庭，父母都是从农村走出来，现在是我所在的这座山东小县城的政府工作人员，具备山东人特别是农村人的淳朴、善良、勤劳、乐观、进取等种种传统美德。良好的家教使我成为一个活泼、可爱、懂事、勤奋的女孩。在学习上，我从小学到高中都保持着优秀的成绩，没用父母过多的操心；在日常生活中我从小养成了自理、自立的习惯，没有成为一个“娇小姐”；在学校里，我兴趣爱好广泛，积极参加各种文体活动，长期担任班干部，热心集体事务，主动帮助其他同学，高中时被学校党组织发展为预备党员，没有成为一个自私自利的“小气鬼”；

在课余时间，我喜欢读书（也许是受爸爸影响，我读了很多古今中外名著），通过阅读，我了解了一些古今中外的人文历史、自然风物，开阔了视野，丰富了思想，使我没有成为一个“书呆子”。我先后获得荣誉称号。以上就是我——一个“丑小鸭”的素描自画像。

我之所以选择报考浙江大学的自主招生，不仅仅因为浙江大

学位于被誉为“上有天堂、下有苏杭”的杭州市，可以在大学的几年时间里徜徉在西子湖畔，尽情领略江南的灵山秀水，充分接受江南文化的滋润；也不仅仅因为浙江大学是国家“211工程”和“985工程”建设的重点大学，拥有一流的教学设备和师资力量，在这里可以接受最优秀的大学教育，毕业后谋取一份好工作；更重要的是因为浙江大学具有悠久深厚的人文历史积淀，竺可桢、马寅初、苏步青、钱三强、王淦昌、贝时璋、谈家桢、姜亮夫、李政道、吴健雄、路甬祥……单单这一串耳熟能详的大师的名字就令我向往不已——记得初中课本学过一篇课文，说气象学家竺可桢去世前一天还坚持记气象日记——原来，竺可桢就是浙江大学的老校长，有这样治学严谨的学者做过校长，还有那一脉相承、内涵丰富的“求是、创新”的校训，浙江大学人才辈出、令人向往就是必然的了。“天行健，君子以自强不息；地势坤，君子以厚德载物。”一个人不能仅仅满足于物质生活的享受，还应该具有“身无分文、心忧天下”的理想情怀。我相信，在这里我可以倾听历史的声音、感悟大师的教诲、养成受用一生的人文精神。我是学

文科的，非常向往进入浙江大学这样具有深厚人文气息和文化底蕴的大学深造。

“洞房昨夜停红烛，待晓堂前拜舅姑。妆罢低声问夫婿，画眉深浅入时无？”

此时，我也怀着那新媳妇拜见公婆一样忐忑不安的心情真诚接受浙江大学领导和老师们的审视。“天道酬勤”，我相信经过我的努力，我的愿望定会实现。

再次感谢浙江大学的领导与老师们！

此致

敬礼！

申请人：一中高 班学生

2011年12月10日

第二篇：申请国外大学博士的计划书[本站推荐]

Research Interest Proposal I am the Doctor degree applicant Xu Zhiwei. From September 2008 to June 2013, I studied the laboratory medicine at Nantong University. In September 2013 I was recommended to the graduate school by the professors due to my excellent assessment. Through undergraduate studies, I contacted such theories as molecular biology,

This planned research has the following aims: The deubiquitinating enzyme USP14 has been identified and biochemically studied, but its mechanisms in cancer remains to be elucidated. Protein glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) is a reversible post-translational modification occurring onserine or threonine residues. Intriguingly, it has been observedthat O-GlcNAcylation is particularly abundant on cancer cells. The aim of this study was to evaluate the O-GlcNAcylation of USP14 in patients with cancer and to define its mechanisms in cancer cell proliferation and apoptosis.

a. To demonstrate that O-GlcNAcylation of USP14. b. To explore Interplay between USP14 O-GlcNAcylation and phosphorylation c. To determine

how

O-GlcNAcylation

regulates

metabolic reprogrammingand Signaling in cancer cells. d. To test whether O-GlcNAcylation regulates proliferation and apoptosis.

2. Research Context

Deregulating cellular energetics is emerging as a characteristichallmark of cancer cells. Withinsuch cells, glucose and glutamine are used at an increasedrate, resulting in the production ofATP in a manner independent of oxygen concentration. Elevated glucose and glutamine flux areneeded not only to serve the energetic demands of cancer cells,but also to provide the essential carbon and nitrogen used inmacromolecule synthesis, fueling the rapid growth and proliferation seen in tumors. This increasein glucose and glutamine uptake can alter multiple metabolicand signaling pathways in cancer cells, including for examplethe hexosamine biosynthetic pathway (HBP). The HBP relies on glucose and glutamine uptake, and approximately 3%–5% of the total glucose entering a cell is shunted intothis pathway. This critical metabolite isrequired for the biosynthesis of a variety of extracellular glycopolymers, including both N- and O-glycans, however, it also serves as the substrate for O-linked b-N-acetlyglucosamine

(O-GlcNAc)

transferase

(OGT).

O-GlcNAcylation is directly involved in growth hormone (gibberellic acid) signalling in plants, and both SPY and SECRET AGENT(SEC) encode O-GlcNAc transferases. Mutations in either SPY or SECcause severe growth defects; simultaneous mutation of both genes islethal. Unlike plants, mammals and insects seem to have only a single gene encoding the catalytic subunit of the O-GlcNAc transferase(OGT) Gene disruption in

mice

established

that

OGT

is

required forembryonic-stem-cell viability20. Tissue-targeted disruption in miceshowed that O-GlcNAcylation is essential to several cell types. OGTdeletion causes hyperphosphorylation, which is followed by cell death, induces T-cell apoptosis and causes growth arrest infibro blasts. Cre–lox-mediated deletion of OGT in cultured fibroblastsresults in death as pre-existing OGT protein levels diminish. This modification can be removed by theglycoside hydrolase O-GlcNAcase (OGA) that catalyzes cleavage of O-GlcNAc from proteins. This modification can alter protein functiondirectly or, in some cases, by competing with phosphorylationsites. O-GlcNAc and O-phosphate site-mapping studies suggest that there areat least four different types of dynamic interplay between O-GlcNAcand O-phosphate . First, there is competitive occupancy at thesame site, for example that which occurs in the transcription factorc-Myc25 and oestrogen receptor-β26, and on the oncoprotein SV-40 largeT-antigen27 and endothelial nitric oxide synthase28. Second, competitiveand alternative occupancy occur at adjacent sites, such as that observedin the tumour suppressor p53 and synapsin I. Third,there is a complex interplay whereby some O-phosphate attachmentsites on a given protein are the same as some O-GlcNAc sites, whereasothers are adjacent to, or even distant from, each other, such as on theC-terminal domain of RNA polymerase II and on cytokeratins32. The final type of interplay involves proteins in which this relationship has yet to be clearly defined. The interplay between O-GlcNAcand O-phosphate is also underscored by the recent finding that OGTtransiently forms complexes containing the catalytic subunit of proteinphosphatase 1 (PP1c). Cancer cells, however, uptake glucose at a higher rateand produce lactic acid rather than metabolizing pyruvate throughthe tricarboxylic acid(TCA) cycle. This adaptive metabolic shift is termed the Warburg effect, leading to anaerobic glycolysis, and is thought toprovide an evolutionary advantage to cancer cells by providingboth increase bioenergetics and biosynthesis. Many protooncogenes (e.g., Ras and Myc) and tumor suppressors (e.g., p53)influence metabolism,and mutations in these genes can upregulateglucose uptake in cancer cells and promote a metabolic phenotype supporting

tumor

cell

growth

and

proliferation. Elevatedglucose uptake in cancer cells can be applied to monitor the location of primary and metastatic tumor sites; for an example, usingF-18 fluorodeoxyglucose (FDG), a glucose analog, with a combination of positron emission tomography/computed tomography(PET/CT). Recent study has providedinsights into the mechanism ofpost-translational modification of molecules in cancer cells theregulation of many molecules and

suggested

important

implications

in

cancer development.Additionally, lines ofevidence of global proteomic analysis havesuggested that post-translational modifications of USP14 are likely not limited to phosphorylation.Other forms of modifications, such asO-GlcNAcylationappear to occur as well,suggesting a more sophisticated regulatorynetwork of USP14. In this study, we would evidence that O-GlcNAcylation within cancer cells regulates cancer cell metabolism via regulation of phosphorylation and its downstream target genes. Mechanistically, we wonder which signaling pathway has participated in the regulation. Furthermore, we will discuss whether decreased O-GlcNAcylation leads to reduced proliferation and apoptosis incancer cells. In addition, we hypothesized that human cancers containing high USP14 levels also containelevated OGT and O-GlcNAcylation. Importantly, we will explore in overallcancer patients, lower OGA expression correlates withpoor clinical outcome. Thus,we will confirm that O-GlcNAcylation serves as a criticallink between the key pathways thatare critical for cancer cell survival via regulation of glycosylation. Method: a. To demonstrate that O-GlcNAcylation of USP14. Here, the O-GlcNAc moietyon the protein is labelled with UDP-GalNAz using a mutantgalactosyltransferase GalT1 Y289L (mGalT1) with an azidederivative of UDP-GalNAc (UDP-GalNAz) as donor substrate,followed by labelling with biotin alkyne. After in vitro O-GlcNAcylation, USP14 was subjectedto mGalT1 labelling and then detected by probing withstreptavidin-conjugated HRP. b. To explore Interplay between USP14 O-GlcNAcylation and phosphorylation. Wewill explore that whether increasing USP14 O-GlcNAc modification with GlcN orPUGNAc treatment inhibits NF-κB activation and have delineatedthe molecular mechanisms of this effect. We will demonstrate that USP14 is a target for O-GlcNAc modification inGlcN or PUGNAc treated cells, and that this post translationalmodification prevents its phosphorylation in response to TNF-α,suggesting a reciprocal relationship between O-GlcNAcylation andphosphorylation of USP14 in cancer cells. We would further showthat, in cancer cells pretreated with GlcN or PUGNAc, levels of O-GlcNAcylation and phosphorylation of USP14 was changed.

c. To determine

how

O-GlcNAcylation

regulates

metabolic reprogrammingand Signaling in cancer cells. Since OGT and O-GlcNAc has been associated with regulationof metabolic diseases such as insulin resistance, we hypothesized that OGT could serve as an importantregulator of glycolytic metabolism to regulate cancer cell growth.To test this idea, we initially examined the effect of OGT reduction on metabolites from human cancercells using liquid chromatography-mass spectrometry (LC-MS). The metabolic profile of cancer cellscontaining OGT knockdown with RNAi demonstrated a generaldecrease in glycolytic and pentose phosphate pathway (PPP)metabolites and an increase in tricarboxylic acid(TCA) cycle metabolites, consistent with a reversalof the Warburg effect and inhibition of cancer cell growth underthese conditions that we and othershave previously shown. d. To test whether O-GlcNAcylation regulates proliferation and apoptosis. Glucose deprivation and antiglycolytic drugs can selectivelyinduce tumor cell proliferation and death; thus, we examined the effect of reducing O-GlcNAcylation on proliferation and apoptosis in nontransformed immortalized mammary epithelial cells compared tocancer cells. In cancer cells stablyexpressing control siRNA or OGT siRNA at day 8 post-infection,we we tested whether cell rounding and detachment of cancer cells containing OGT knockdown, while cancer cells attached to the plate. To further investigate the effect of OGT SiRNA on cellular proliferation, we used chemically synthesized siRNA to knockdown endogenous OGT in cancer cells. The efficiency of the OGT-targeted siRNA-mediateddown-regulation was assessed by Western blot analysis. Aspredicted, siRNA knocked down the protein expression of OGT as compared with negative control siRNA and mocktreatment. To determine the effect of OGT knockout on cancer cell proliferation, OGT-siRNA, negative control-siRNA and mock treatment cancer cell proteins were testedby Western blot. We would explore that expressed decreased OGT levels hadelevated cleaved caspase-3 and caspase-8, and upto 50%–70% of cells were examined for annexin V.

第三篇：美国大学申请推荐信信息表

College Recommendation Sheet

Your

Name::Your Email Address:

List according to the due date for when I must send them out]:

College/University Due DateCollege/University Due Date

1.9.2.10.

3.11.4.12.

5.13.

6.14.7.15.

8.16.

Which class(es) did you take with me?

Class: Year: Final Average: AP Exam Grade:

Listwords that describe you as a student/as a person: [Be VERY SPECIFIC!]

List and identify if you were an officer:

ACTIVITY GRADE YEAR OFFICER [what position?]

What other extra-curricular activities have you engaged in these past few years in your community or at your church?

What do you plan to major in?:

WHY did you choose that major?:

What are your long-term career goals/plans?:[Give me details and go into some real depth in your explanation.]

Tell me some things about yourself that I don’t know, but are interesting or unique about you [go into !This is your time to pat yourself on the back a bit].Who are you as a person outside of my classroom and outside of CVCS??:

What did you do in my class that made you “stand out?”What activities/projects were you most proud of class(es)?:

List anything else that you can think of that may be important to me as I compose your college letter of recommendation:

第四篇：高中生出国留学申请大学推荐信

Recommendation LetterOct20.2011

English Teacher : Gaofang

Student Name: DengluDate of Birth:

To Whom it may Concern:

After serious consideration, I recommend Denglu to your university for further study.

It is a pleasure to have such an excellent student as Denglu in our class. She is

intelligent, diligent, attentive and has a strong enthusiasm in learning. With class work she is conscientious, alert and focused on the tasks.Her homework is thorough and punctual for she well understands the importance of this work in assisting her with her learning and she has developed competence in her exam technique with excellent time management skills.

In her English learning, she has a particular talent. Her vocabulary is broad and she is keen to both learn and use new words as a means of extending it. It is her aim to improve her speaking even though she is quite fluent. She reads well; is able to effectively scan and skim passages; and she appreciates the tone and attitude of the writer. As she enjoys writing, she is able to express her ideas clearly; to carefully argue a case; and her sentence and paragraph organization is excellent. Additionally, she not only works hard in English but also in all her other subjects. She actively takes part in class activities and is capable of learning by herself after class.

Deng is a friendly and well-mannered student with a great sense of humor, so she is very popular with others. She has obvious leadership qualities and she is always willing to make a positive contribution to class activities. In my English class she often has a great deal to offer her classmates and readily shares her understanding of language situations. She has been English homework and task monitor for more than two years and I really appreciate her assistance in my English teaching. Moreover, I am deeply impressed by her persistence, work efficiency and huge sense of responsibility.

Meanwhile, Deng enjoys participating in a diverse range of activities such as the

School Science Festival, the Sports Meeting and the Basketball Matches. We are very proud of her due to her wonderful performances in these activities as well as the

academic field, which always bring her lots of brilliant prizes. What has impressed me most is her exceptional speech in the 2009 School Opening Ceremony which she delivered as the only representative on behalf of all the students.

As far as I am concerned, Deng not only has an outstanding learning talent, but has the

confidence and ability to continue to develop this talent and if she maintains her ambition, she will become a highly competent student in the internationally academic environment. Therefore, I sincerely recommend Denglu to your university.

第五篇：优秀大学生入党申请例文-入党申请（推荐）

入党申请是优秀大学生入党申请例文 敬爱的党支部;

我志愿加入中国共产党，愿意为共产主义奋斗终身。我衷心的热爱党，她是中国工人阶级的先锋队，是中国各族人民利益的忠实打败，是中国社会主义事业的领导核心。中国共产党是中国社会主义建设的核心。以毛为代表的中共党人，推翻三座大山，建立人民民主专政的新中国，开辟了中华民族奋发图强的新纪元。新中国成立后，党进行大规模的社会主义建设，使一个备受欺辱的半封建半殖民地国家一跃成为在国际舞台上占有举足轻重地位的社会主义国家。

我们党是伟大的党，是无产阶级的先锋队，是我们由中华民族优秀的先进分子所组成的，它代表着最广泛的人民利益，有着光荣革命传统的党。加入党组织是我为之努力奋斗的方向。为此，我向党组织郑重提出申请加入中国共产党，请求组织对我严格审查。

自5.12四川省汶川大地震后，让我对中国共产党有了更深刻的了解，给了我更大鼓午。在中国共产党的领导下，从中央到灾区的市县，乡、镇均成立了各级抗镇，救灾指挥部，协调指挥各方面的力量，使得救灾工作迅速而有效的进行。那场大地震，震撼了我们每个中华儿女的心，牵动了那么多的爱。我注意到那次灾难后，不顾个人安危，站斗在最危险，最艰苦的地方是共产党员，舍己救人，公而忘私多的是共产党员，更有获救群众在救出后说的第一句话就是;‘我要加入中国共产党!’

共产党的魅力折服了我，共产党员的精神鼓舞着我!在进入21世纪的中，使我再次看到了共产党员的先锋模范作用，看到了共产党员的先进性，在危难关头表现得特别突出。政党做为国家执政的裁体，是国家稳定的基础喝执政能力的保障。正是我们人民有着这样一个强有力的政党，才能使中国人民面对这样的残酷的自然灾害，能同呼吸共患难。这既是一个民族的伟大精神，也是对祖国稳定和发展的认可。在救灾工作的最前沿，出现了很多可歌可泣的英雄人物事迹。我不知道在他们中谁是共产党员，可我知道，在那样的大灾面前没有一个有力的组织和领导，就不可能取得那样举国同心救灾的场面。而这种强有力的领导只有在中国共产党的领导下才能完成。

在我记事开始的1998年抗洪救灾开始到现在所发生的一切天灾人祸，使我更加透彻的理解了中国共产党的先进性。中国共产党不亏是中国工人阶级的先锋队，是中国各族人民利益代表，是中国社会主义事业的领导核心。

作为二十一世纪的大好青年，我们应该大题细作，“从我做起”，随时为党和国家的利益、人民事业奉献自己的一切，为把我国建设成为现代化强国而刻苦努力学习。由于了解党的光辉历史，结合我的成长过程，我对党敬仰已久。通过对党章、党纲、党史及有关文件的学习，我对共产党的性质、任务等有了更进一步的提高。

我深知按照中国共产党员的要求，自己有很大的差距，还有很多的不足和缺点。我希望党组织从严要求我，使我能更快的进步，积极搞好本职工作，尊从党的教诲，努力纠正生活工作的缺点和错误。开展批评和自我批评。提高各方面业务水平，发扬社会主义新风尚，提倡共产主义道德。我会牢记;我是一个在中国共产党领导下的中国人。会在以后的学习生活中，时时刻刻以马克思列宁主义，马思想，邓理论做为自己的行动指南。支持以中国共产党为领导的一切活动，争取成为一名光荣的中国共产党远!

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